-Aula Introdutória

- Apresentação da disciplina

- Entrega de artigos para seminários

- Divisão dos trabalhos finais

1) What Is the Best Strategy for Preclinical Testing of

Botanicals? A Critical Perspective

2) Targeting the Human Genome−Microbiome Axis for Drug Discovery:

Inspirations from Global Systems Biology and Traditional Chinese

Medicine

1) Aucubin, a naturally occurring iridoid glycoside inhibits TNF-a-induced

inflammatory responses through suppression of NF-jB activation in 3T3-L1

adipocytes. Cytokine 62 (2013) 407–412

2) Natural Products as a Source of Anti-Inflammatory Agents

Associated with Inflammatory Bowel Disease. Molecules 2013, 18, 7253-7270

3) Nobiletin and tangeretin ameliorate scratching behavior in mice

by inhibiting the action of histamine and the activation of NF-κB,

AP-1 and p38. International Immunopharmacology 17 (2013) 502–507

4) Inhibition of Carrageenan-Induced Acute In�ammation in Mice

by Oral Administration of Anthocyanin Mixture from Wild

Mulberry and Cyanidin-3-Glucoside. 

BioMed Research International

(2013) 1-10

1) Effects of Curcumin on Apoptosis and Oxidoinflammatory Regulation

The Roles of c-Jun N-Terminal Kinase and p38 Mitogen-Activated Protein Kinase in a Rat Model of Acetic Acid–Induced Colitis. J Med Food 16 (4) 2013, 296–305

2) Anti-inflammatory, gastroprotective and anti-

ulcerogenic effects of red algae Gracilaria changii

(Gracilariales, Rhodophyta) extract. BMC Complementary and Alternative Medicine 2013, 13:61.

3) Gastroprotective and anti-Helicobacter pylori

potential of herbal formula HZJW: safety and

efficacy assessment. BMC Complementary and Alternative Medicine 2013, 13:119.

4) Prokinetic and laxative effects of the crude

methanolic extract of Viola betonicifolia whole

plant in rodents. BMC Complementary and Alternative Medicine 2013, 13:70

1) Antinociceptive effect of Butea monosperma on vincristine-induced neuropathic pain model in rats. Toxicol Ind Health 2013 29:3-13

2) The Endocannabinoid System,

Cannabinoids, and Pain. Rambam Maimonides Med J. 2013 4: 1-15.

3) Mechanism underlying anti-hyperalgesic and anti-allodynic properties

of anomalin in both acute and chronic inflammatory pain models in

mice through inhibition of NF-κB, MAPKs and CREB signaling cascades. European Journal of Pharmacology 718 (2013) 448–458.

4) Antinociceptive, neurobehavioral and antioxidant effects

of Eupatorium triplinerve Vahl on rats. Journal of Ethnopharmacology 147 (2013) 293–301.

1) Antidepressant-like effect of flavonoids extracted from Apocynum

venetum leaves on brain monoamine levels and dopaminergic system. Journal of Ethnopharmacology 147 (2013) 108–113

2) Anxiolytic-Like Effect of a Salmon Phospholipopeptidic

Complex Composed of Polyunsaturated Fatty Acids and

Bioactive Peptides. Mar. Drugs 2013, 11, 4294-4317.

3) Orcinol glucoside produces antidepressant effects by

blocking the behavioural and neuronal deficits caused

by chronic stress. European Neuropsychopharmacology, 2013: 1-9.

4) Anxiolytic-like effect of lavender essential oil inhalation in mice:

Participation of serotonergic but not GABAA/benzodiazepine

neurotransmission. Journal of Ethnopharmacology 147 (2013) 412–418.

1) Rehmannia Glutinosa Extract Activates Endothelial

Progenitor Cells in a Rat Model of Myocardial Infarction

through a SDF-1 a/CXCR4 Cascade. PLOS ONE (2013) 8(1):1-15

2) Acute and chronic antihypertensive effects of

Cinnamomum zeylanicum stem bark methanol

extract in L-NAME-induced hypertensive rats. BMC Complementary and Alternative Medicine 2013, 13:27

3) Super, Red Palm and Palm Oleins Improve the Blood

Pressure, Heart Size, Aortic Media Thickness and Lipid

Profile in Spontaneously Hypertensive Rats. PLOS ONE (2013) 8(2):1-12

4) Sweet Chestnut (Castanea sativa Mill.) Bark Extract:

Cardiovascular Activity and Myocyte Protection against

Oxidative Damage. Oxidative Medicine and Cellular Longevity, (2013): p.2-11

1) Role of standardized grape polyphenol preparation

as a novel treatment to improve synaptic plasticity

through attenuation of features of metabolic syndrome

in a mouse model. Mol. Nutr. Food Res. 2013, 00, 1–12

2) Camel milk ameliorates steatohepatitis, insulin

resistance and lipid peroxidation in experimental

non-alcoholic fatty liver disease. BMC Complementary and Alternative Medicine 2013, 13:264

3) Populus balsamifera Extract and Its Active Component

Salicortin Reduce Obesity and Attenuate Insulin

Resistance in a Diet-Induced Obese Mouse Model. Evidence-Based Complementary and Alternative Medicine. (2013): 1-14

4) Water extract of Spatholobus suberectus inhibits

osteoclast differentiation and bone resorption. BMC Complementary and Alternative Medicine 2013, 13:112

1) Artemisia leaf extract induces apoptosis in human endometriotic cells

through regulation of the p38 and NFkB pathways. Journal of Ethnopharmacology 145 (2013) 767–775.

2) Dracaena arborea alleviates ultra-structural

spermatogenic alterations in

streptozotocin-induced diabetic rats. BMC Complementary and Alternative Medicine 2013, 13:71.

3) Antifertility effect of hydroalcoholic leaves extract of

Michelia champaca L.: An ethnomedicine used by Bhatra women in

Chhattisgarh state of India. Journal of Ethnopharmacology 147 (2013) 671–675.

4) Mucuna pruriens and Its Major Constituent L-DOPA

Recover Spermatogenic Loss by Combating ROS, Loss of

Mitochondrial Membrane Potential and Apoptosis. PLOS ONE, 2013(8):1-10.

1) Potential Changes in Rat Spermatogenesis and Sperm

Parameters after Inhalation of Boswellia papyrifera and Boswellia

carterii Incense. Int. J. Environ. Res. Public Health 2013, 10, 830-844.

2) Evaluation of the Toxicity ofPradosia huberiExtract during

the Preimplantation in Wistar Rats. BioMed Research International,

2013, p. 1-6.

1) Inhibition of HIV-1 Replication by Secondary Metabolites From

Endophytic Fungi of Desert Plants. The Open Virology Journal, 2013, 7, 72-80.

2) Holarrhena antidysenterica as a resistance modifying agent against Acinetobacter baumannii: Its effects on bacterial outer membrane permeability and efflux pumps. Microbiological Research, 2013, p.1-8.

1) Antiprotozoal Activity of Quinonemethide Triterpenes from

Maytenus ilicifolia (Celastraceae). Molecules 2013, 18, 1053-1062.

2) High Content Analysis of Primary Macrophages Hosting

Proliferating Leishmania Amastigotes: Application to

Anti-leishmanial Drug Discovery. PLOS Neglected Tropical Diseases, 2013(7):1-11.

1) In vivo antitumor activity of biosynthesized silver nanoparticles using Ficus religiosa as a nanofactory in DAL induced mice model. Colloids and Surfaces B: Biointerfaces. 108(2013):185-190.

- Discussão das principais metodologias empregadas no estudo da avaliação da toxicidade sistêmica aguda, subaguda e crônica de produtos naturais.

- Discussão e instruções para a elaboração de artigos de revisão sobre alguns temas pertinentes à disciplina, como trabalho final complementar da mesma.