MECANISMOS CELULARES E MOLECULARES

CICLO E SINALIZAÇÃO  CELULAR

1           Genotoxic Anti-Cancer Agents and Their Relationship to DNA Damage, Mitosis, and Checkpoint Adaptation in Proliferating Cancer Cells

2           Drug-induced cell cycle modulation leading to cell-cycle arrest, nuclear mis-segregation, or endoreplication

3           Defective Cell Cycle Checkpoints as Targets for Anti-Cancer Therapies

4           Checkpoints couple transcription network oscillator dynamics to cell-cycle progression

5           Checkpoint kinase 1 in DNA damage response and cell cycle regulation

1. The Replication Fork Understanding the Eukaryotic Replication Machinery and the Challenges to Genome
2.  Organization of DNA Replication

1. Molecular Mechanisms of DNA Replication Checkpoint Activation
2. DNA Replication Timing, Genome Stability and Cancer

1. DNA Damage Response and Spindle Assembly Checkpoint Function throughout the Cell Cycle to Ensure Genomic Integrity

1         Transcription Start Site Sequence and Spacing between the −10 Region and the Start Site Affect Reiterative Transcription-Mediated Regulation of Gene Expression in Escherichia coli

2         Transcription as a source of genome instability

3         Regulation of gene expression by reiterative transcription

4         Cell growth- and differentiation-dependent regulation of RNA polymerase III transcription

5         Basic Mechanisms in RNA Polymerase I Transcription of the Ribosomal RNA Genes

1           Tinkering with Translation: Protein Synthesis in Virus-Infected Cells

2           Global Genetic Determinants of Mitochondrial DNA Copy Number

3           Improved Cell-Free RNA and Protein Synthesis System

4           Mechanism of Cytoplasmic mRNA Translation

5           Small RNAs derived from the 5′ end of tRNA can inhibit protein translation in human cell

1           Genotoxic Anti-Cancer Agents and Their Relationship to DNA Damage, Mitosis, and Checkpoint Adaptation in Proliferating Cancer Cells

2           Chromatin structure and DNA damage repair

3           DNA double-strand break repair pathway choice and cancer

4           Repair of Oxidative DNA Damage and CancerRecent Progress in DNA Base Excision Repair

5           Systemic DNA damage responses Organismal adaptations to genome instability

6           Oxidative stress, DNA damage, and the telomeric complex as

therapeutic targets in acute neurodegeneration

1         Epigenetic regulation of genomic integrity

2         The Epigenetics of Renal Cell Tumors from Biology to Biomarkers

3         Molecular marks for epigenetic identification of developmental and cancer stem cells

4         Epigenetics and environmental chemicals

5         Epigenomics The science of no-longer-“junk” DNA. Why study it in chronic kidney disease

1         Evolutionary foundations for cancer biology

2         Driver mutations of cancer epigenomes

3         Proteomic Approaches in Biomarker Discovery: New Perspectives in Cancer Diagnostics

4         Risk factors for delay in symptomatic presentation: a survey of cancer patients

5         Molecular pathways and therapeutic targets in lung cancer

1         Molecular and Cell Signaling Targets for PTSD Pathophysiology and Pharmacotherapy

2         Measuring information flow in cellular networks by the systems biology method through microarray data

3         Deregulation of Cell Signaling in Cancer

4         Comparison of human cell signaling pathway databases—evolution, drawbacks and challenges