Banca de DEFESA: AURILEIDE MARIA BISPO FRAZÃO SOARES

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
DISCENTE: AURILEIDE MARIA BISPO FRAZÃO SOARES
DATA: 26/05/2023
HORA: 08:30
LOCAL: Auditório do PPGQ
TÍTULO: IMOBILIZAÇÃO DA ENZIMA PAPAÍNA EM SUPORTE HÍBRIDO CONSTITUÍDO DE NANOPARTICULAS DE ÓXIDO DE ZINCO E QUITOSANA PARA CASTRAÇÃO QUÍMICA DE CÃES
PALAVRAS-CHAVES: zinc oxide nanoparticles, chitosan, papain, biomedical applications
PÁGINAS: 100
GRANDE ÁREA: Ciências Exatas e da Terra
ÁREA: Química
SUBÁREA: Química Inorgânica
ESPECIALIDADE: Físico Química Inorgânica
RESUMO:

A new hybrid bionanomaterial composed of zinc oxide nanoparticles (ZnO NPs) and chitosan was constructed after enzymatic immobilization of papain for biomedical applications. In this work, we report the preparation and characterization steps of this bionanomaterial and its biocompatibility in vitro. The properties of the immobilized papain system were investigated by transmission electron microscopy, zeta potential, DLS, UV-vis absorption spectroscopy, FTIR spectroscopy, and X-ray diffraction. The prepared bionanomaterial exhibited a nanotriangular structure with a size of 150 nm and maintained the proteolytic activity of papain. In vitro analyses demonstrated that the immobilized papain system decreased the activation of phagocytic cells but did not induce toxicity. Based on the results obtained, we suggest that the novel bionanomaterial has great potential in biomedical applications in diseases such as psoriasis and wounds. 

MEMBROS DA BANCA:
Interno - 2157495 - ANDERSON NOGUEIRA MENDES
Interno - 1357378 - CARLA VERONICA RODARTE DE MOURA
Interno - 1551616 - CHISTIANE MENDES FEITOSA
Externo ao Programa - 3107513 - DALTON DITTZ JUNIOR
Externo à Instituição - DURCILENE ALVES DA SILVA - UFDPar
Interno - 1714193 - JOSE MILTON ELIAS DE MATOS
Externo ao Programa - 2199134 - MARCILIA PINHEIRO DA COSTA
Presidente - 1508806 - WELTER CANTANHEDE DA SILVA