Banca de DEFESA: LOURDES CRISTINA DA S LOPES

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE: LOURDES CRISTINA DA S LOPES
DATA: 20/08/2015
HORA: 14:30
LOCAL: Auditório da Química
TÍTULO:

Facile green route of metallic nanoparticles using tannic acid: characterization and evaluation of the cytotoxic and antileishmanial activities

PALAVRAS-CHAVES:

metallic nanoparticles, green route, leishmania amazonensis, nanotechnology

PÁGINAS: 75
GRANDE ÁREA: Ciências Exatas e da Terra
ÁREA: Química
SUBÁREA: Química Inorgânica
ESPECIALIDADE: Química Bio-Inorgânica
RESUMO:

In this work, we focuse the investigation of the antileishmanial potential of noble metal nanoparticles (Ag and Au) synthesized by a green route, employing a polyphenolic compound (tannic acid, TA) as stabilizer. This investigation is due to the toxicity and ineffectiveness of the drugs currently administered in the parasitosis treatment, which are also expensive. Leishmaniases are severe parasitic diseases that affect people worldwide and are caused by protozoa of the Leishmania genus. Studies with these hybrid nanomaterials can lead to a range of possibilities to improve the therapeutic of the disease and, thus the patients life quality. The nanoparticles formation and their interaction with the tannin were monitored by spectroscopic and imaging techniques. In vitroassays with leishmania amazonensis promastigotes resulted in IC₅₀ values of 221.81±97.08 µg mL^-1 and 5.51±1.67 µg mL^-1 for TA and AgNPs-TA respectively, thus confirming the increment of the antileishmanial activity about 40 times by AgNPs-TA, while AuNPs-TA did not present antileishmanial activity in none tested concentration.

MEMBROS DA BANCA:
Presidente - 1508806 - WELTER CANTANHEDE DA SILVA
Interno - 1357378 - CARLA VERONICA RODARTE DE MOURA
Externo ao Programa - 1167750 - FERNANDO AECIO DE AMORIM CARVALHO
Externo à Instituição - HILRIS ROCHA E SILVA - FACID