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[(p)11.3(r)11.9(es)-8.4(en)18(ts)-274(o)9.9(t)-7.2(her)-274.5(t)-7.2(hera)18.4(p)-9.5(e)-0.1(u)11.1(t)-6.3(ic)-273.1(p)11.3(r)11.9(o)9.9(p)-9.5(er)-10.7(t)-6.3(i)-0.8(es)-274(s)5.1(u)-0.7(c)6(h)]TJ -7.1133 -1.141 TD -0.003 Tc [(as)-353.3(a)6(n)15.5(t)-8.8(i)-8.7(hemo)8.3(r)-9.6(r)0.3(hag)-8.4(i)-3.3(c)-347.9([)]TJ 0 g 8.5306 0 TD 0 Tc ()Tj 0 0 0 1 k 0.4969 0 TD -0.009 Tc [(])-9.1(,)-360.1(an)9.5(t)-14.8(i)-9.3(oph)-8.9(i)-9.3(d)-8.6(i)-12(an)-357.3([)]TJ 0 g 6.7491 0 TD 0 Tc (\015)Tj 0 0 0 1 k 0.4544 0 TD 0.0007 Tc [(],)-349.5(a)9.7(n)19.2(t)-5.1(i)7.6(vira)-4.8(l)-347([)]TJ 0 g 4.9496 0 TD 0 Tc ()Tj 0 0 0 1 k 0.4951 0 TD 0.0001 Tc [(],)-350.1(a)9.1(n)3.3(d)]TJ -21.6756 -1.141 TD -0.0088 Tc [(an)9.7(t)-14.6(i)-9.1(m)-9.2(i)-9.1(c)-8.6(r)3.6(obi)-11.8(a)-14.3(l)-232.8([)]TJ 0 g 5.9451 0 TD 0 Tc ()Tj 0 0 0 1 k 0.4643 0 TD 0.0001 Tc (].)Tj 20.9908 11.1251 TD -0.0004 Tc 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[(M.)-161.1(glo)9.8(m)7(er)18.7(a)21.6(t)9.4(a)]TJ /F4 1 Tf 5.3381 0 TD -0.0104 Tc [(we)-10(re)]TJ -22.2169 -1.2006 TD -0.0004 Tc [(iden)18.1(t)-6.2(i)-0.7(e)-5.4(d)-386.6(a)2.3(s)-385.9(c)-0.2(o)10(u)-0.6(ma)8.6(r)-7(i)-0.7(n,)-384.9(l)11.4(u)11.1(p)-9.4(e)-5.4(o)6.4(l)-386.1(acet)-7.1(a)18.5(t)5.6(e)]TJ /F1 1 Tf 15.8996 0 TD 0 Tc (o)Tj /F4 1 Tf 0.4698 0 TD -0.0003 Tc [(-h)22.4(y)7.9(d)0.1(r)12.1(o)15.5(x)-24.3(y-cinna)8.7(mic)]TJ -16.3694 -1.2512 TD 0.0001 Tc [(acid)-163.9([)]TJ 0 g 2.1672 0 TD -0.0056 Tc ()Tj 0 0 0 1 k 0.8266 0 TD -0.0003 Tc [(],)-164.4(ka)18.6(ur)12.1(eno)11(i)-0.6(c)-164.5(a)-0.3(cid)-164.3([)]TJ 0 g 7.0328 0 TD -0.0001 Tc ()Tj 0 0 0 1 k 0.6748 0 TD -0.0004 Tc [(],)-164.5(cinna)8.6(m)2.8(o)15.4(y)-7.5(lg)-5.8(ra)8.6(ndio)10.9(r)-7(ic)-164.6(acid)6.4(,)-164.5(a)8.6(nd)]TJ -10.7014 -1.2512 TD -0.0052 Tc [(st)-11(i)-5.5(g)-10.6(maste)-4.8(r)7.2(ol)-304.2([)]TJ 0 g 5.5106 0 TD 0.0026 Tc ()Tj 0 0 0 1 k 0.8058 0 TD -0.0112 Tc [(])-11.3(.)-312.6(M)15.3(o)-11.6(s)-5.6(t)-312.4(of)-311.4(t)-17.9(h)-7.5(e)-10.8(s)-19.1(e)-310.7(c)-11(om)7.4(p)-20.2(o)-0.8(u)-11.4(n)-8(d)-8.1(s)-310(we)-10.8(re)-311.6(prove)-10.8(n)-311.6(t)-5.2(o)]TJ -6.3164 -1.2503 TD -0.0031 Tc [(ha)14.9(ve)-246.6(pha)5.9(r)-9.7(macolog)-8.5(i)-3.4(c)-5.6(a)-8.6(l)-245.2(a)-3.1(c)-10.1(t)-8.9(iv)-6.2(i)8.3(t)-6.2(y)-33.7(:)-245.8(l)8.7(u)8.5(p)-12.1(e)-8.1(ol)-246.1(has)-246.8(a)5.9(n)15.4(t)-8.9(i-in)-5.8(a)5.9(mma)15.8(t)2.9(o)8.2(r)-32.3(y)]TJ 0 -1.2512 TD 0.0039 Tc [(acti)10.8(vi)15.3(ty)-510.9([)]TJ 0 g 3.7906 0 TD -0.0001 Tc (\012)Tj 0 0 0 1 k 0.7905 0 TD -0.0185 Tc [(])-18.6(;)-534.9(k)-18.5(a)0.4(u)-18.7(r)-6.1(e)-18.1(n)-15.3(o)-7.2(i)-18.8(c)-532.3(a)-18.5(c)-18.3(i)-18.8(d)-534.8(i)-16.1(s)-535(a)-534.4(p)-27.5(o)-8.1(t)-12.5(e)-18.1(nt)-24.3(i)-21.5(a)-24(l)-533.4(a)-9.5(nt)-24.3(i)-18.8(m)-18.9(i)-18.8(c)-18.3(r)-6.1(o)-13.5(b)-6.5(i)-21.5(a)-24(l)-12.1(,)]TJ -4.581 -1.2512 TD -0.0083 Tc [(h)14.4(y)-8.2(p)-17.3(o)2.1(te)-7.9(ns)-8.1(ive,)-437.1(an)-5.1(d)-435.2(a)0.7(n)10.2(t)-14.1(i)-8.6(-)-8.2(i)-8.6(n)-8.8()-11(a)0.7(m)-8.7(m)-6(a)10.6(t)-2.3(or)-37.5(y)-38.9(;)-433.4(c)-8.1(o)2.1(u)-8.5(m)-6(ar)-14.9(i)-8.6(n)-434.2(i)-5.9(s)-435.4(an)-437(an)10.2(t)-14.1(i)-8.6(-)]TJ 0 -1.2015 TD -0.0003 Tc [(ina)8.7(mma)18.6(t)5.7(o)11(r)-29.5(y)73(,)-617.9(imm)18.3(u)-0.5(nos)5.3(u)11.2(p)10.6(p)11.5(r)12.1(e)0.1(s)5.3(s)-0.1(i)6.6(v)7.4(e)6.4(,)-617(a)8.7(n)18.2(t)-6.1(i)-6(h)22.4(y)-0.2(p)-9.3(e)0.1(r)-10.5(t)5.7(en)7.4(si)6.6(v)7.4(e)6.4(,)-617.9(a)8.7(nd)]TJ ET Q endstream endobj 4 0 obj <>stream q 1 0 0 -1 0 792 cm -100 Tz q q 1 0 0 -1 500.05 100 cm 100 Tz /Fm0 Do Q Q Q endstream endobj 5 0 obj <>stream x}K@䖃EEVHLm)6![[EŃ߮_2Ûf H|WP UBQN IA'}a\D 2pkG<8C f'=rs~?k@PnBF9%sϼS+rȃf#&dљ3c;Ԍ3{sV5lwdvD*ځQz(1oqb6I*KԷN\-q#=j: