Banca de DEFESA: PEDRO JOSÉ GOMES RODRIGUES

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
DISCENTE: PEDRO JOSÉ GOMES RODRIGUES
DATA: 24/02/2022
HORA: 14:00
LOCAL: Sala remota: meet.google.com/hvy-kjga-vwo
TÍTULO: ELECTRODEPOSITION OF BACTERICIDAL AND BIOACTIVE NANO-HYDROXYAPATITE ONTO ELECTROSPUN PIEZOELECTRIC POLYVINYLIDENE FLUORIDE SCAFFOLDS
PALAVRAS-CHAVES: Polyvinylidene Fluoride; Nano-Hydroxyapatite; Nanotechnology; Electrospinning; Electrodepositio; Bactericidal; Bone Regeneration.
PÁGINAS: 74
GRANDE ÁREA: Engenharias
ÁREA: Engenharia de Materiais e Metalúrgica
SUBÁREA: Materiais Não-Metálicos
ESPECIALIDADE: Polímeros, Aplicações
RESUMO:

The fibrous scaffolds for bone tissue engineering (TE) that mimic the extracellular matrix with bioactive and bactericidal properties could provide adequate conditions for regeneration of damaged bone. Electrospun ultrathin fibers covered with nano-hydroxyapatite is a favorable fibrous scaffold design for TE applications . We developed a fast and reproducible strategy to produce polyvinylidene fluoride (PVDF)/nano-hydroxyapatite (nHAp) nanofibrous scaffolds with bactericidal and bioactive properties. Fibrous PVDF scaffolds were obtained firstly by the electrospinning method. Then, their surfaces were modified using oxygen plasma treatment followed by electrodeposition of nHAp. This procedure formed nanofibrous and superhydrophilic PVDF fibers (133.6 nm, fiber average diameter) covered with homogeneous nHAp (202.6 nm, average particle diameter) crystals. Energy-dispersive X-ray spectrometry demonstrated the presence of calcium phosphate, indicating a Ca/P molar ratio of approximately 1.64. X-ray diffraction, Fourier transform infrared spectroscopy, and Raman spectroscopy spectra identified β-phase of nHAp. Thermal analysis indicated a slight reduction in stability after nHAp electrodeposition. Bactericidal assays showed that nHAp exhibited 99.8% efficiency against Pseudomonas aeruginosa bacteria. The PVDF/Plasma and PVDF/nHAp groups had the highest cell viability, total protein, and alkaline phosphatase activity by 7 days after exposure of the scaffolds to MG63 cell culture. Therefore, the developed scaffolds are an exciting alternative for application in bone regeneration.

MEMBROS DA BANCA:
Presidente - 1397472 - ANDERSON DE OLIVEIRA LOBO
Interno - 1113300 - FERNANDA ROBERTA MARCIANO
Interno - 6276167 - ROMULO RIBEIRO MAGALHÃES DE SOUSA
Externo à Instituição - LUANA MAROTTA REIS DE VASCONCELLOS - UNESP
Externo à Instituição - RODRIGO SAVIO PESSOA - ITA